TFG::ALK fusion in ALK positive large B-cell lymphoma: a case report and review of literature

TFG::ALK fusion in ALK positive large B-cell lymphoma: a case report and review of literature

Blog Article

Anaplastic lymphoma kinase (ALK) positive vx bonnet protector large B-cell lymphoma (ALK+ LBCL) is an aggressive and rare subtype of B-cell lymphoma.Patients typically present with advanced clinical stage disease and do not respond to conventional chemotherapy; the median overall survival is 1.8 years.The genetic landscape of this entity remains poorly understood.Here we report a unique case of ALK+ LBCL harbouring a rare TFG::ALK fusion.

Targeted next-generation sequencing showed no significant single nucleotide variants, insertions/deletions, or other structural variants beyond the TFG::ALK fusion; deep deletions of FOXO1, PRKCA, and the MYB locus were also detected.Our case report draws attention to this rare disease, highlights a need veuve ambal rose for larger genetic profiling studies, and focuses on the pathogenesis and potential therapeutic targets of this aggressive disease.To our knowledge, this is the first report of a TFG::ALK fusion in ALK+ LBCL.